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Vijay Kumar, M.
- Synthesis, Antibacterial and Antifungal Evaluation of Novel Pyrazoline Derivatives
Abstract Views :197 |
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, IN
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical, Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1481-1484Abstract
A novel series of Chalcones (2a-j) were prepared by reacting Furfuraldehyde and substituted ketones in alcohol medium in presence of NaOH. The Chalcones undergoes selective cyclization with Benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1,3,5-trisubstituted Pyrazolines (3a-j). All the newly synthesized compounds were evaluated for their In-Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis. Some of the tested compounds showed potent activity against antifungal organism A.fumigatus.Keywords
Pyrazolines, Chalcones, Furfuraldehyde, Benzhydrazide, Antibacterial.
- Antiepileptic Activity of Ethanolic and Aqeous Leaves Extract of Annona reticulata Linn
Abstract Views :163 |
PDF Views:0
Authors
Sonal D’Souza
1,
Jennifer Fernandes
1,
M. Vijay Kumar
1,
Nishmitha Gretta D’Souza
1,
Ronald Fernandes
1
Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 241-244Abstract
The present study was evaluated for the Antiepileptic activity of methanolic and aqeous extracts of leaves Annona reticulata on the seizures induced by chemical and electroconvulsive method i.e PTZ and MES methods. In this study, the antiepileptic study of methanolic and aqeous extract of Annona reticulata at doses of 100mg/kg, 200mg/kg and 400mg/kg using the PTZ and MES models were investigated in Swiss Albino Rats. The %protection of the rats was found to increase with an increase in the dose. It was found that at the dose of 400mg/kg, both the extract of the leaves showed very good activity and most animals showed no signs of convulsions. The obtained data from the study suggested the reduction in the duration and delay in the latency of the seizures.Keywords
Annona Reticulata, Antiepileptic Activity, MES, PTZ.References
- Porwal M, Sharma K.Evaluation of anticonvulsant activity of Annona squamosa linn. leaves in mice. J Cell Tissue Res. 2011;11(2):2879-2884.
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- Verma S, Singh SP. Current and future status of herbal medicines. Veterinary World. 1(11): 347-350.
- Rao S, Subbalakshmi K. An experimental study of the anticonvulsant effect of amlodipine in mice. Singapore Med J 2010; 51(5): 424-8.
- Jhamkhande PS, Wattamwar AS, Chandak PG.The invitro anthelmintic efficacy of ethno-medicinal plant Annona reticulata ischolar_mains against Indian earthworms. IJNPR. 2014; 5(2):152-157.
- Thang TD, Kuo PC, Huang GJ, Hung NH, Huang BS, Yang ML et al. Chemical constituents from the leaves of Annonareticulata and their inhibitory effects on NO production. Molecules. 2013;18:4477-4486.
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- Girish SA, Sudhir G, Wadodkar, Avinash KD. Evaluation of sedative and anticonvulsant activities of UnmadnashakGhrita. J Ethnopharmacol. 2004; 94: 77-83.
- Suresh AR, Karki SS. Anticonvulsant activity of various extracts of leaves of Calotropisgigantea Linn. against seizure induced models. Int J Pharm Sci. 2011; 3(3): 200-203.
- In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus
Abstract Views :393 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, IN
1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3265-3267Abstract
Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.Keywords
in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.References
- Krishnamoorthy SR, Sarala P. Phytochemical studies of Artocarpus gomezianus wall. ex Trecul. var. lakoocha Roxb. fruits collected from various altitudes of central western ghats. Indian Journal of Natural Products and resources.2013, 4(4): 398-411
- Taksim Ahmed, Mohammad Nasir Uddin, Shaikh Faisol Ahmed, Arindam saha, Kaniz Farhana, Md.Sohel Rana. Invitro evaluation of antioxidant potential of Artocarpus charma Buch. fruits. Journal of Applied Pharmaceutical Sciences 2012, 2(10): 75-80.
- Hashim NM, Mawardi Rahmani, Cheng LE, Sukari MA, Maizatulakmal Yahayu, Muhamad AMA, Ali AM, Rusea G. Antioxidant, Antimicrobial and tyrosinase inhibitory Activities of xanthones isolated from Artocarpus obtusus F.M. Jarrett: Molecules. 2012, 17, 6071-6082.
- Unnikrishnan PS, Suthindhiran K, Jayasri M. Alpha-amylase inhibition and antioxidant activity of marine green algae and its possible role in diabetes management. Pharmacog. Mag. 2015 Oct, 11(4): S511-S515.
- Madhusudhan Telagari and Kiran Kumar Hullatti. In vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. Extracts and fractions. Indian Journal of Pharmacology. 2015 Jul-Aug, 47(4):425-429.